+ indicates faculty members of the UCLA NIEHS training grant in "Molecular Toxicology"

+ Patrick Allard, Ph.D.

Society and Genetics, Environmental Health Sciences - Full Biography

In the Allard laboratory, we are using the nematode C. elegans to uncover mechanisms of germ cell maintenance and differentiation. By developing and applying novel genetic, cellular and molecular tools in the nematode, we attempt to gain fast mechanistic insight on germline genes and pathways that are disrupted during environmental exposure. We are also interested in exploring environmental influence on other aspects of cellular differentiation and function. For example, we are examining the effect of environmental chemicals on the deregulation of fat homeostasis, in particular exposures to compounds leading to fat accumulation ("obesogens").

Anne M. Andrews, Ph.D.

Psychology and Biobehavioral Science - Full Biography

Dr. Andrews' research is centered on the investigation of therapeutics, drugs of abuse, neurotoxins, and environmental factors to probe the molecular basis of serotonin system function associated with the etiology and treatment of mood and anxiety disorders.

+ Jesus A. Araujo, MD, Ph.D.

Medicine, Environmental Cardiology - Full Biography

Dr. Araujo's research program focuses on the study of genetic and environmental factors involved in vascular oxidative stress and atherosclerosis, including the dissection of molecular mechanisms responsible for the cardiovascular toxicity of air pollutants.

+ Jeff Bronstein, M.D., Ph.D.

Neurology - Full Biography

Jeff Bronstein received his bachelor's degree from the University of California, Berkeley and M.D. and Ph.D. from UCLA as a recipient of the Medical Scientist Training Program Award. He completed a residency in Neurology and fellowship training in Movement Disorders at UCLA and at Queens Square in London. Dr. Bronstein also completed a postdoctoral fellowship in molecular biology before being appointed an Assistant Professor of Neurology in 1994 and Director of the Movement Disorders Program in 1996 at UCLA. His clinical interests include the management of Parkinson's disease (PD) and other movement disorders, surgical treatment of PD, and developing new therapies for patients. Dr. Bronstein's research interests include the study of the causes of PD (environmental and genetic) using cell and zebrafish models as well as population-based studies. His research is supported by the NIH, Veteran Administration, and private foundations. Dr. Bronstein is the Principle Investigator of one of 6 National Parkinson's Disease Centers (PADRECC) at the Veterans Administration Medical Center, is a project PI of the UCLA Collaborative Center for Parkinson's Disease Environmental Research (CCPDER) funded by the NIEHS and is an Investigator in the UCLA Udall Center.

Gautam Chaudhuri, M.D.

OB/GYN and Pharmacology - Full Biography

Dr. Chaudhuri's research focuses on the mechanism by which estradiol and nitric oxide modulate various physiological functions and the signal transduction pathways involved.

+ Marie-Francoise Chesselet, Ph.D.

Chair-Neurobiology; Charles H. Markham Professor, Neurology - Full Biography

Dr. Chesselet's laboratory explores molecular mechanisms leading to neurodegenerative diseases of the basal ganglia, such as Huntington's disease and Parkinson's disease She is interested in the mechanisms by which environmental toxins, specifically agricultural pesticides, may interact with genetic risk factors to cause increased risks of Parkinson's disease. This work is primarily conducted in mouse models of Parkinson's disease but also involves neuronal cultures.

Catherine Clarke, Ph.D.

Chemistry and Biochemistry - Full Biography

Coenzyme Q (also known as ubiquinone or Q) is a lipid component of cellular membranes that plays an essential role in the respiratory electron transport chain. Dr. Clarke studies the biosynthesis, regulation, and function of Q in the yeast Saccharomyces cerevisiae.

Michael Collins, Ph.D

Environmental Health Sciences - Full Biography

Research in Dr. Collins' laboratory is concerned with aspects of developmental toxicology or teratology.

Curtis Eckhert, Ph.D.

Environmental Health Sciences - Full Biography

Dr. Eckhert's research program is concerned with elucidating the molecular basis of boron essentiality and toxicity in humans and animals.

Richard Gatti, Ph.D.

Pathology and Labortory Medicine - Full Biography

Dr. Gatti's research focuses on ataxia-telangiectasia and other chromosomal instability disorders. The lab specializes in diagnostic assays, mutation screening and identification, genetic mechanisms of disease, and functional assays for ATM and related proteins, including cellular responses to ioinizing radiation. Another project identifies therapeutic approaches to ATM based on specific groups of mutations.

Ben Glasgow, M.D.

Pathology and Laboratory Medicine - Full Biography

Dr. Glasgow's laboratory investigates the role of proteins in the molecular mechanisms of tear film formation. The interactions of tear proteins in ocular surface diseases are studied using a range of biophysical, biochemical, molecular and microscopic techniques. Current focus is centered on tear lipocalin, a promiscuous transporter of hydrophobic ligands in the human tear film.

Hilary Godwin, Ph.D.

Environmental Health Sciences - Full Biography

Dr. Godwin's research focuses on the basic chemical and biological mechanisms by which toxic metal ions affect neurological signaling and development and the mechanisms by which nanoparticles enter living systems and impact biological processes.

+ Oliver Hankinson, Ph.D.

Molecular Toxicology Ph.D. Program Director , and Department of Pathology and Laboratory Medicine - Full Biography

Dr. Hankinson's research focuses on the mechanism of carcinogenesis by polycyclic aromatic hydrocarbons (found in cigarette smoke and smog) and dioxin (a widespread pollutant) and related compounds, using molecular biology, cell culture and animal model systems.

Louis J. Ignarro, Ph.D.

Molecular and Medical Pharmacology - Full Biography

Dr. Ignarro's research is directed toward elucidating mechanisms of regulation of nitric oxide (NO) production and cytotoxicity in macrophages, vascular cells, and tumor cells.

+ David Krantz, Ph.D.

Psychiatry and Biobehavioral Sciences - Full Biography

Dr. Krantz uses Drosophila to study how changes in the function of neurotransmitter transporters may influence synaptic transmission and behavior.

Shaily Mahendra, Ph.D.

Civil and Environmental Engineering - Full Biography

Dr. Mahendra's research areas are focused on microbiomes in natural and engineered systems, applications of molecular and isotopic tools in environmental microbiology, environmental toxicology of nanomaterials, and biotransformation of water contaminants.

William McBride, Ph.D

Radiation Oncology - Full Biography

Dr. McBride's research focuses on degradation of proteins through the proteasome system and the inhibitory effects of exposure to radiation, and other agents.

William Melega, Ph.D.

Molecular and Medical Pharmacology - Full Biography

Dr. Melega studies the molecular mechanisms of neurodegenerative diseases and drug addiction.

Sabeeha Merchant, Ph.D.

Chemistry and Biochemistry - Full Biography

Dr. Merchant studies the biochemistry and molecular genetics of metal metabolism.

+ Jeffrey H. Miller, Ph.D.

MIMG - Full Biography

Dr. Miller's group is interested in understanding how mutations occur in cells of bacteria, and how cells avoid mutagenesis with different repair strategies. We are also interested in understanding repair systems in humans, and how defects in these systems lead to cancer.

+ Andre Nel, MD, Ph.D.

Medicine - Full Biography

Dr. Nel's research focuses on the adverse effects of particulate pollutants, including manufactured nanoparticles and diesel exhaust particles, to the lung.

Frank Pajonk, M.D., Ph.D

Radiation Oncology/Division of Molecular and Cellular Oncology - Full Biography

Dr. Pajonk's research is focussed on radiation effects of the proteasome and cancer stem cells.

Suzanne E. Paulson, Ph.D.

Atmospheric Sciences - Full Biography

Dr. Paulson's group is investigating generation of reactive oxygen species by ambient particulate matter, mapping air pollution in urban microenvironments, and investigating aerosol optical properties.

Srinivasa Reddy, Ph.D.

Molecular and Medical Pharmacology - Full Biography

Dr. Reddy's laboratory studies physiological and pathological phenomena mediated by arachidonic acid (AA) and its metabolites, which are implicated in a number of disease processes including acute and chronic inflammation, cardiovascular disease, immune response, arthritis, inflammatory bowel disease, respiratory disorders and cancer.

+ Beate Ritz, MD., Ph.D.

Epidemiology and Environmental Health - Full Biography

Dr. Ritz's primary research interests are the effects of occupational and environmental toxins such as pesticides, ionizing radiation, and air pollution on chronic diseases including neurodegenerative disorders (Parkinson's disease), cancer, and adverse birth outcomes.

Wendie Robbins, Ph.D.

Nursing/ Environmental Health Sciences - Full Biography

Dr. Robbins' research focuses on the molecular mechanisms of environmentally induced germ cell genetic damage and the development of biomarkers to detect and measure this damage in human sperm cells.

Michael Roth, M.D

Medicine - Full Biography

Dr. Roth's research focuses on the toxicology of inhaled substance abuse.

+ Ram Raj Singh, MD.

Pathology/ Environmental Health Sciences - Full Biography

His research on immune pathogenesis of lupus and autoimmune diseases and mechanisms of tolerance has been recognized by over a dozen national and international awards, including Carol Nachman Prize, one of the largest international prize in experimental rheumatology that he received from the President of Germany.

+ Robert Schiestl, Ph.D.

Pathology/ Environmental Health Sciences - Full Biography

Dr. Schiestl's work centers mostly on basic mechanisms, genetic control, and inducibility by environmental carcinogens and nanoparticles of homologous and illegitimate recombination, which are molecular events involved in carcinogenesis.

Xia Yang, Ph.D.

Integrative Biology and Physiology - Full Biography

Dr. Yang's research focuses on identifying key regulatory genes and gene networks that mediate the effect of genetic and environmental perturbations on metabolic diseases using high-throughput genomic and computational approaches. Dr. Yang is also interested in applying similar approaches to pharmacogenomic and toxicogenomic studies to understand the genomic architecture of drug metabolism, drug response, and toxicity.

Zuo-Feng Zhang, Ph.D.

Epidemiology - Full Biography

Dr. Zhang's research interests focus on molecular genetic epidemiology of cancers of the lung, bladder, prostate, esophagus, stomach, liver, head and neck cancer, cervix, and AIDS-related malignancies. His research team is working on the role of mutations, methylations, and polymorphisms of genes in the development of cancer. The major focus of his research group is to evaluate the main effects of these genes on the risk of cancers and to assess potential gene-environment interactions. Dr. Zhang is also interested in risk and protective factors for major cancers such as cancers of the lung, esophagus, stomach, and liver in Chinese population, nutrition and cancer, epidemiology of second primary cancers, methodological issues in the use of tumor markers in cancer epidemiology, and the application of tumor markers in progression and survival of cancer.